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Scientists identify new potentially effective remedy for COVID-19

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The COVID-19 pandemic has created the need for antiviral therapeutics that can be swiftly moved into the clinic. It has led many researchers to search for a candidate through drug repurposing or screening clinically approved antivirals for efficacy against SARS-CoV-2. While traditional antivirals, like remdesivir, target viral enzymes that are often subject to mutation. Thus, to develop drug resistance, antivirals that target the cell host proteins required for viral replication could have benefits, such as avoiding the development of resistance.

Working in preclinical models, researchers report that plitidepsin, a drug with limited clinical approval for the treatment of multiple myeloma, is more potent against SARS-CoV-2 than remdesivir—an antiviral that received FDA emergency use authorization for the treatment of COVID-19 in 2020.

The work is published in Science in the article, “Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eFF1A.”

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Another Azerbaijani judoka wins medal

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Azerbaijani judoka Mammadali Mehdiyev (90 kg) won a bronze medal at the Grand Slam tournament in Tashkent, Uzbekistan.

Report informs that the 28-year-old athlete defeated Uzbekistan's Shermuhammad Jandreev in the match for third place.

Mehdiyev's medal is Azerbaijan's second in the Tashkent Grand Slam. On March 6, Rustam Orucov (73 kg) also won a bronze medal for Azerbaijan.

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Oncologist reveals alarming symptoms of tongue cancer

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Neoplasms, cracks, and bruising in the mouth may indicate the development of tongue cancer, Report informs, citing Russian oncologist Mikhail Myasnyankin.

According to the specialist, the first signs of oncology appear as cracks in the mucous membrane of the tongue and pain around them. Bad breath and bleeding appear in the later stages.

“The main risk factors for developing tongue cancer include smoking, especially along with strong alcohol, chewing various mixtures, and background diseases,” Myasnyankin said.

He also noted that sometimes poor-quality prostheses are the cause of oncology.

“With this type of cancer, people might find it difficult to speak clearly and even eat independently. In such a case, it is necessary to consult a doctor at the first symptoms,” the specialist advised.

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Footage from liberated Suma village of Azerbaijan’s Aghdam district

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The Azerbaijani Defense Ministry has prepared video footage from the village of Suma in Azerbaijan's Aghdam district liberated from the Armenian occupation.

Report presents the footage below:

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