The match is being played at the Tofiq Bahramov Republican Stadium, with a 21:45 local kick off, as the Azerbaijani champions look to take a step toward the group stage against Premier League opposition, News.Az reports.
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Qarabağ are seeking to use home advantage and strong European experience, while Newcastle aim to secure a positive result on their return to the Champions League knockout rounds.
The second leg will decide which side progresses to the next stage of the competition in what is expected to be a closely contested playoff.
