The strike targeted the truck in Beit Jinn village in southwestern Syria, with at least one person reported injured in the attack, Al Jazeera reported.
The incident comes days after Israel carried out airstrikes on Syria’s Abu al-Duhur military airbase on Aug. 18.
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The earlier Israeli strikes targeted the runway and storage areas at the abandoned airbase in eastern Idlib province, according to Syrian officials.
The latest drone attack adds to continued Israeli military activity in Syrian territory amid heightened regional tensions.
